Prevalence of Thalassemia Traits in People without Anemia or
نویسنده
چکیده
Introduction Thalassemia is a group of genetic disorders resulting in the decreased production of globin chains, alpha or beta, leading to the decreased production of hemoglobin (Hb). For the heterozygous state, it can be recognized by the microcytosis of its red blood cell or the decreased mean corpuscular volume (MCV) of less than 80 fL. For alpha-thalassemia-1 or alpha(0)thalassemia traits, they have slightly low or normal Hb level (Hb 10.3 + 1.9 g/dL) with mild hypochromia (MCH 25.9 + 2.1 pg) and microcytosis (MCV 69.2 + 4.0 fL) whereas in beta-thalassemia traits, only two of 450 beta-thalassemic patients have the MCV >78 fL. Therefore the MCV < 80 fL may be used as the cut point for screening alpha-thalassemia-1 and betathalassemia traits with the sensitivity, specificity, the positive predictive value (PPV) and the negative predictive values (NPV) of 92.9%, 83.9%, 37.9% and 99.1%, respectively. When the MCV less than 78.1 fL is used to screen for alpha-thalassemia-1 and beta thalassemia, it cannot detect all cases because its sensitivity and specificity are demonstrated to be 93.0% and 93.4%, respectively. In addition, the MCV of beta thalassemia traits is shown to range from 56.3 to 87.3 fL which overlaps that of the normal people. Moreover, the MCH < 27 pg is demonstrated to have more sensitivity (98.5%) than the MCV < 80 fL (97.6%) for screening beta-thalassemia. Because, the various thalassemias and hemoglobinopathies are strikingly prevalent in Thailand (the prevalence 61.1 62.2%), just only few percentages of thalassemia or hemoglobonopathy which are possibly unrecognized by any screening method can become a serious problem, this paper OriginalArticle PrevalenceofThalassemiaTraitsinPeoplewithoutAnemiaor Microcytosis
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